ACT — Aspergillus nidulans FGSC A4
Summary
The Aspergillus nidulans gene ACT (ANIA_06542) on chromosome 1 encodes actin (acnA), a structural constituent of the cytoskeleton with ATP-binding and hydrolase activity. It is associated with cell motility, endocytosis, cell division, DNA repair-dependent chromatin remodeling, and regulation of transcription. The encoded protein localizes to the actin cytoskeleton, actomyosin contractile ring, hyphal tip, and chromatin-remodeling complexes such as INO80 and SWR-C. Phenotypic associations include delayed cytokinesis and protein secretion, decreased cell cycle progression, abnormal sporulation efficiency, and absent cell fusion and anaerobic growth. Related genes in other species link the family to reduced virulence and oxidative stress response.
Annotations
- Chromosome
- 1
- Related genes
- ACT, act, TCP1, NHP10, SLT2, HOF1, YFR016C, DRN1
- GO terms
- ATP Binding, Regulation Of DNA-templated Transcription, Hydrolase Activity, Chromatin, actomyosin contractile ring, proximal layer, chromatin modeling, Site Of Polarized Growth, Mating Projection Tip
- Publications
- 19822674, 19214209, 34849884, 27365394, 22244335, 32737079, 22451923, 19297522
- Traits
- RESISTANCE TO CHEMICALS: DECREASED, COMPETITIVE FITNESS: DECREASED, STRESS RESISTANCE: DECREASED, INVIABLE, RESISTANCE TO CHEMICALS: INCREASED, CELL CYCLE PROGRESSION: ABNORMAL, NUCLEAR POSITION: ABNORMAL, RESISTANCE TO CHEMICALS: NORMAL