UAPC — Aspergillus nidulans FGSC A4

Summary

ANIA_06730 (symbol UAPC, also known as XUT1 or AnUAPC) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a member of the NCS2 (nucleobase-cation symporter-2) family, specifically a xanthine/urate permease. The encoded protein possesses urate and xanthine transmembrane transporter activity, binds purine bases, and is associated with the transport of hypoxanthine, xanthine, urate, and pyrimidine nucleobases. It is linked to mycotoxin anabolism and endocytosis. The protein localises to the plasma membrane, endosome membrane, vacuolar membrane, and fungal-type vacuole. Studies of related genes in other species connect the NCS2 family to similar nucleobase transport functions.