UAPC — Aspergillus nidulans FGSC A4

Summary

ANIA_06932, symbol UAPC in Aspergillus nidulans FGSC A4 on chromosome 1, encodes a member of the xanthine/urate permease (Xan_ur_permease) and NCS2 transporter families. The gene product possesses urate and xanthine transmembrane transporter activities, purine base binding, and purine base transmembrane transporter activity. AnUAPC is associated with the transport of hypoxanthine, pyrimidine nucleobases, xanthine, urate, and purine bases generally. It has also been linked to mycotoxin anabolism and endocytosis. The protein localises to the endosome membrane, vacuolar membrane, fungal-type vacuole, and plasmalemma. Related genes in other species, including Verticillium dahliae and Fusarium oxysporum, are linked by sequence similarity.