IST2 — Aspergillus nidulans FGSC A4

Summary

AnIST2 (ANIA_07165) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a plasma membrane stress response protein (Ist2) belonging to the anoctamin family, with annotated phospholipid scramblase activity. The gene is associated with phospholipid translocation, exocytosis, secretion, and endocytosis, and localises to the endoplasmic reticulum, cortical ER, and ER-plasma membrane contact sites (EPCS). Related genes in other species are linked to plasma membrane channel function, though these roles are not established for AnIST2 itself.