PAP1 — Aspergillus nidulans FGSC A4

Summary

ANIA_07513 (AnPAP1) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a bZIP transcription factor of the AP-1-like family, with DNA-binding transcription activator activity specific to RNA polymerase II. It is associated with the regulation of sexual and asexual sporulation, pigmentation, and carbohydrate utilization. The gene is linked to the anabolism of emericellin and shamixanthone, while also being connected to the inhibition of asperthecin and sterigmatocystin formation. AnPAP1 is associated with cellular responses to cadmium, singlet oxygen, and amino acid starvation, as well as lipid oxidation and immune evasion. It localizes to the nucleus, cytoplasm, and chromatin, and is part of transcription regulator complexes. Related genes in other species link the family to oxidative stress response and calcium sensitivity.