AMYC — Aspergillus nidulans FGSC A4

Summary

ANIA_07576 (AnAMYC, also known as AnLRG1) on chromosome 4 of Aspergillus nidulans encodes an uncharacterized protein with a Znf_LIM domain and a RhoGAP domain, and is annotated with small GTPase binding, GAP activity, and metal binding. The gene is associated with positive regulation of establishment of bipolar cell polarity regulating cell shape, regulation of actin cable assembly, regulation of actin cytoskeleton organization, negative regulation of cell integrity MAPK cascade, regulation of cell wall organization or biogenesis, hyphal growth, morphogenesis, signal transduction, and glucan breakdown and anabolism. The encoded protein localizes to the cell cortex, cell tip, division septum, and sites of polarized growth. Phenotypic associations include abnormal bipolar budding pattern, absent cell fusion, delayed nuclear fusion during mating, abnormal filamentous growth, abnormal pseudohyphal growth, decreased adhesion, and abnormal chitin deposition. Studies of related genes in other species link the family to acid sensitivity.