SNZ1 — Aspergillus nidulans FGSC A4

Summary

ANIA_07725 (SNZ1, also known as pyroA) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a pyridoxal 5'-phosphate synthase with glutamine-hydrolysing and amine-lyase activity, belonging to the PdxS/SNZ family. The gene is associated with vitamin B6 and vitamin A metabolism, pyridoxine and pyridoxal phosphate biosynthesis, amino acid metabolism, and fermentation. The product localises to the cytosol, the Sno1p-Snz1p complex, and the extracellular space. Phenotypic associations include increased vegetative growth rate, altered cell cycle progression (including G1/S phase delay and metaphase arrest), increased aneuploidy, decreased telomere length, abnormal actin cytoskeleton and endoplasmic reticulum morphology, reduced biofilm formation, and altered nutrient utilisation. Related genes in other species link the family to oxidative stress response.