dcp1 — Aspergillus nidulans FGSC A4

Summary

ANIA_07746 (symbol dcp1) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a putative decapping enzyme Dcp1, a member of the PH-like domain superfamily, with mRNA phosphatase activator activity, enzyme activator activity, and mRNA binding. The gene is associated with mRNA methylguanosine-cap decapping, both deadenylylation-dependent and independent decapping, nonsense-mediated mRNA decay, nuclear and general mRNA breakdown, rRNA breakdown, RNA processing, and secondary metabolism. Its product localises to P bodies, stress granules, the cytosol, and the nucleus, and has been observed in the Dcp1-Dcp2 complex. Related genes in other species, including Verticillium dahliae and Fusarium oxysporum pathovars, are linked to the Dcp1 family.