palC — Aspergillus nidulans FGSC A4

Summary

ANIA_07560 (palC) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a protein containing a BRO1 domain, placing it in the BRO1 superfamily. The gene is associated with cellular response to pH, intracellular signaling, signal transduction, and regulation of gene expression. It has been linked to endocytosis, autophagy, secretion, hyphal growth, mating, and proteolysis. The encoded protein localises to the ESCRT III complex and the plasma membrane. palC is also associated with regulation of secondary metabolite biosynthesis, activation of penicillin anabolism, chromatin modelling, and hypersensitivity. Studies of related genes in other species link the palC family to pH-responsive regulation.