HAPB — Aspergillus nidulans FGSC A4

Summary

ANIA_07545 (HAPB, AnHAPB) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes the transcriptional activator HAP2, a member of the NFYA protein family. The product possesses DNA-binding transcription activator activity specific to RNA polymerase II, promoter-enhancer loop anchoring activity, and sequence-specific DNA binding. It localises to the nucleus as part of the CCAAT-binding factor complex and is also associated with heterochromatin. AnHAPB is associated with the regulation of aerobic respiration, carbohydrate metabolism, lysine and penicillin anabolism, nuclear import, and positive regulation of transcription by RNA polymerase II. The gene has also been linked to the oxidative stress response. Related genes in other species further associate this family with transcriptional regulation.