FHPA — Aspergillus nidulans FGSC A4

Summary

ANIA_07169 (FHPA, AnFHPA) on chromosome 4 of Aspergillus nidulans encodes a protein with globin and FAD/NAD-binding reductase domains, and with nitric oxide dioxygenase [NAD(P)H] activity (EC 1.14.12.17), oxygen binding, FAD binding, and heme binding. AnFHPA is associated with nitric oxide breakdown, cellular detoxification of nitrogen compounds, response to nitrosative stress, alternative respiration, gluconeogenesis, heterotrophy, filamentous growth, and sterigmatocystin anabolism. It is linked to negative regulation of sexual sporulation and has been connected to mitochondrial localization. Phenotypic associations include decreased fermentative and respiratory metabolism, increased pheromone sensitivity and mating response, increased flocculation, abnormal budding, increased autophagy, decreased gamma ray resistance, increased hyperosmotic stress resistance, absent pseudohyphal growth, G1 and G2/M cell cycle arrest, decreased stationary phase survival, increased mitotic recombination, increased chitin deposition, and increased telomere length. Studies of related genes in other species link the family to oxidative stress response and reduced virulence.