DAL5 — Aspergillus nidulans FGSC A4

Summary

ANIA_07380 (DAL5) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a major facilitator superfamily (MFS) domain-containing protein with L-cysteine, dipeptide, and carboxylic acid transmembrane transporter activity. The gene is associated with nitrogen catabolite repression, catabolite repression, regulation of growth, and membrane transport of L-cysteine, dipeptides, and carboxylic acids. The product localises to the plasma membrane, ER, Golgi complex, cell tip, and cell division site. AnDAL5 is associated with decreased utilisation of sulfur and nitrogen sources, abnormal mitochondrial transport and genome maintenance, decreased pexophagy, reticulophagy, and mitophagy, increased stress, metal, and toxin resistance, increased replicative and chronological lifespan, altered competitive fitness, and abnormal vacuolar morphology and vegetative growth. Studies of related genes in other species link the family to nitrogen source utilisation and chitin deposition.