GAS1 — Aspergillus nidulans FGSC A4

Summary

ANIA_07511 (GAS1, AnGAS1) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a glucanosyltransferase with 1,3-beta-glucanosyltransferase activity (EC 2.4.1.-), belonging to the glycoside hydrolase superfamily and X8 domain family. The gene is associated with fungal-type cell wall assembly and 1,3-beta-glucan metabolism, as well as lipid modification, cell morphogenesis, division septum assembly, and establishment or maintenance of cell polarity. It is linked to host invasion, adhesion of symbiont to host, single-species biofilm formation, and cellular responses to pH and calcium ions. The product localises to the cell septum edging, primary cell septum, new and old growing cell tips, sites of polarized growth, vesicles, and the external side of the plasma membrane. Phenotypic associations include abnormal filamentous growth, increased fermentative growth, and absent alkaline pH resistance. Related genes in other species are linked to reduced virulence and leaf necrosis.