uaY — Aspergillus nidulans FGSC A4

Summary

ANIA_07189 (uaY) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a Zn(II)2Cys6 transcription factor with DNA-binding transcription repressor activity specific to RNA polymerase II. The gene is associated with hypoxanthine transport, purine base breakdown, pigmentation, and cellular response to oxidative stress. It has been linked to both positive and negative regulation of transcription by RNA polymerase II, as well as regulation of gene expression and DNA-templated transcription. Additional associations include response to ammonia, negative regulation of cellular response to drug, endocytosis, methylation, translation termination, and gene conversion. The encoded protein localises to the nucleus, membrane, and cytosol. Studies of related genes in other species link the family to reduced virulence.