HIS2 — Aspergillus nidulans FGSC A4

Summary

AnHIS2 (ANIA_07044) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a histidinol-phosphatase (EC 3.1.3.15), a member of the PHP domain and histidinol-phosphate phosphatase HisJ families. The enzyme is annotated to histidinol-phosphatase activity and localises to the cytosol. It is associated with histidine anabolism, nicotinate breakdown, and asexual reproduction. Phenotypic associations link the gene to increased stress and metal resistance, increased replicative and chronological lifespan, altered mitochondrial transport and genome maintenance, decreased pexophagy, reticulophagy, and mitophagy, abnormal liquid culture appearance, decreased respiratory growth and starvation resistance, altered protein/peptide accumulation, abnormal chemical compound accumulation, and both increased and decreased competitive fitness and chemical resistance. Studies of related genes in other species connect the family to increased lifespan, decreased heat sensitivity, and auxotrophy.