CLR-2 — Aspergillus nidulans FGSC A4

Summary

ANIA_06832 (CLR-2, AnCLR-2) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a Zn2Cys6 fungal-type transcription factor with DNA-binding transcription activator activity specific to RNA polymerase II. The protein belongs to the fungal secondary metabolite regulator family and localises to the nucleus, cytosol and fungal biofilm matrix. AnCLR-2 is associated with positive regulation of patulin and thiamin biosynthesis, cellulose breakdown, galactose metabolism, fermentation, secretion, and responses to xenobiotic stimuli. It is also linked to intracellular receptor signalling, RNA-dependent gene silencing, and positive regulation of transcription by RNA polymerase II. Studies of related genes in other species connect the family to altered virulence, including hypervirulence and reduced virulence, as well as to fruit decay and blue mold disease.