CAN1 — Aspergillus nidulans FGSC A4

Summary

ANIA_06757 (CAN1) on Aspergillus nidulans chromosome 1 encodes an amino acid transporter, a member of the AA-permease/SLC12A domain family with transmembrane transporter activity for L-arginine, L-lysine, L-histidine and L-proline. The gene is associated with amino acid membrane transport, including proline import and arginine transmembrane transport, as well as regulation of nitrogen utilization and single-species biofilm formation. The encoded protein localizes to the plasma membrane, eisosome, Golgi membrane, cell tip and endoplasmic reticulum. Studies of related genes in other species link the family to reduced virulence and disseminated candidiasis.