MTO1 — Aspergillus nidulans FGSC A4

Summary

ANIA_06577 (symbol MTO1, AnMTO1) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a mitochondrial translation optimization protein (Mto1) with tRNA 5-taurinomethyluridine synthase activity and FAD/FADH2 binding. The gene is associated with mitochondrial tRNA wobble uridine modification, tRNA methylation, and localizes to the mitochondrial lumen and mitochondria. It has been linked to interphase and mitosis, as well as protein content. Phenotypic associations include abnormal mitochondrial transport and genome maintenance, decreased pexophagy, mitophagy, sporulation, respiratory growth, endocytosis, and nutrient utilization, alongside increased stress resistance, metal resistance, and replicative lifespan. The encoded protein belongs to the MnmG and GidA family, and related genes in other species are linked to abnormal respiratory metabolism, decreased biofilm formation, and decreased chronological lifespan.