CIT3 — Aspergillus nidulans FGSC A4

Summary

ANIA_06650 (CIT3, AnCIT3) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a citrate synthase family protein with both 2-methylcitrate synthase and citrate synthase activities (EC 2.3.3.5, 2.3.3.16). The gene is associated with mitochondrial localisation and multiple metabolic processes including the TCA cycle, glyoxylate cycle, propionate breakdown, propionyl-CoA and CoA metabolism, and citrate metabolism. It is linked to secondary metabolism, polyketide and sterigmatocystin biosynthesis, pigmentation, hyphal growth, meiosis, and carbohydrate metabolism. Phenotypic associations include abnormal colony colour, altered respiratory metabolism, increased cell death and lifespan, changes in carbon source utilisation, decreased sporulation efficiency, altered mitochondrial morphology and genome maintenance, increased desiccation resistance, and modified mitophagy and protein activity.