ASPB — Aspergillus nidulans FGSC A4

Summary

AnASPB (ANIA_06688) on chromosome 1 encodes a septin-type G domain-containing protein with GTPase activity and GTP binding, and it binds phosphatidylinositol phosphates. As a structural constituent of the cytoskeleton, it is associated with cytokinesis, including mitotic actomyosin contractile ring assembly, septin ring assembly and disassembly, and division septum assembly. The gene is linked to conidiophore development, asexual sporulation, and growth of a unicellular organism as a thread of attached cells. It is associated with maintenance of cell polarity, ER polarization, chitin localization, and protein localization to bud neck. Phenotypic associations include abnormal cell cycle progression, increased aneuploidy, altered colony shape, and effects on mating efficiency, desiccation resistance, and sterile outcomes. Studies of related genes in other species link the family to virulence modulation.