SEC7 — Aspergillus nidulans FGSC A4

Summary

ANIA_06709 (SEC7, AnSEC7) encodes a guanyl-nucleotide exchange factor (GEF) containing a Sec7 domain, a DCB domain, and an ARM-type fold, and is annotated with lipid binding. In Aspergillus nidulans, the gene is associated with Golgi organization, cisternal maturation, intra-Golgi transport, ER-to-Golgi transport, exocytosis, endocytic recycling, secretion, vesicle formation, and actin cytoskeleton organization. It localizes to the Golgi membrane, COPI vesicle membranes, and the cell tip and division site. Phenotypic associations include abnormal Golgi morphology, decreased cell cycle progression, increased necrotic cell death, decreased nutrient uptake and nitrogen source utilization, abnormal colony shape, absent budding and cytokinesis, and decreased meiosis. Related genes in other species link the Sec7 family to ARF protein signal transduction and protein transport.