ABZ1 — Aspergillus nidulans FGSC A4

Summary

ABZ1 (pabaA) in Aspergillus nidulans encodes a protein with aminodeoxychorismate synthase activity, anthranilate synthase activity, phosphoribosylanthranilate isomerase activity, and indole-3-glycerol-phosphate synthase activity. The gene is associated with PABA biosynthesis, tetrahydrofolate anabolism, tryptophan formation, pigmentation, hyphal growth, cell cycle, DNA repair, and the DNA damage response. It is linked to the cytoplasm, cytosol, nucleus, and the anthranilate synthase complex. Phenotypic associations include decreased competitive fitness, increased heat sensitivity, reduced autophagy, abnormal RNA localization, decreased telomere length, and delayed G1/S phase transition. Related genes in other species are linked to auxotrophy and abnormal vacuolar morphology.