KAE1 — Aspergillus nidulans FGSC A4

Summary

ANIA_06569, designated KAE1 in Aspergillus nidulans FGSC A4, encodes a protein with t6A synthase and nucleotidase activities, belonging to the KAE1/TsaD and Gcp-like domain families. It is associated with the EKC/KEOPS complex and localises to chromatin, the cytoplasm and the nucleus. The gene is associated with t6A biosynthesis, siderophore metabolism, arginine breakdown, telomere maintenance via recombination, and positive regulation of transcription by RNA polymerase II. Phenotypic associations include decreased lifespan, increased apoptosis, abnormal cell cycle progression, reduced resistance to X-ray and gamma-ray stress, altered protein secretion, and impaired mitochondrial genome maintenance. Related genes in other species connect the family to similar processes including tRNA modification, cell cycle control and stress responses.