LYS2 — Aspergillus nidulans FGSC A4

Summary

ANIA_06521 (LYS2) in Aspergillus nidulans FGSC A4 encodes a homoaconitate hydratase (EC 4.2.1.36), an enzyme that contains a 4Fe-4S cluster and localises to the mitochondrial lumen. This gene is associated with lysine biosynthesis, as well as the production of penicillin and other peptide antibiotics, secondary metabolites, and fatty acids. It is also linked to responses to amino acids, iron levels, and iron ion starvation, and to general homeostasis. Phenotypic associations connect LYS2 to abnormal vegetative growth, sporulation, colony and liquid culture appearance, mitochondrial transport and genome maintenance, decreased respiratory growth, increased apoptosis, altered mitotic recombination, and reduced biofilm formation, pexophagy, reticulophagy, and mitophagy. The gene is further linked to changes in protein activity, RNA accumulation, stress and metal resistance, and nutrient utilisation.