TRS120 — Aspergillus nidulans FGSC A4

Summary

ANIA_06533 (symbol TRS120, also known as AnTRS120) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes an uncharacterized protein that contains Trs120_TRAPPC9_N and multiple characteristic of the TRAPP II complex subunit Trs120. The gene is associated with cisternal maturation, intra-Golgi transport, Golgi-to-plasma membrane transport, secretion, hyphal growth, morphogenesis, autophagy, and cell polarity establishment. It localizes to the TRAPP complex, cis-Golgi network, trans-Golgi network, cleavage furrow, growing cell tip, and cell division site. Phenotypic associations include abnormal Golgi morphology, absent or decreased protein secretion, decreased autophagy and pexophagy, abnormal endocytosis, premature cell cycle progression in metaphase and telophase, increased bipolar budding, and decreased vacuolar transport. Related genes in other species link the family to the TRAPPII protein complex and YPT1-dependent trafficking.