MOD5 — Aspergillus nidulans FGSC A4

Summary

AnMOD5 (ANIA_06513) on chromosome 1 of Aspergillus nidulans encodes a tRNA dimethylallyltransferase, a transferase with ATP-binding and zinc-binding properties that contains a dimethylallyltransferase domain and a C2H2-type zinc finger. The gene is associated with tRNA modification and RNA modification, and its product localises to the nucleolus and mitochondria. AnMOD5 is associated with abnormal RNA modification, decreased chromosome segregation, increased meiotic recombination, altered cell cycle progression, increased resistance to UV, osmotic stress, acid pH, starvation and killer toxin, decreased spore germination and mating response, absent vegetative growth and nitrogen source utilisation, and increased nucleolus size.