AZF1 — Aspergillus nidulans FGSC A4

Summary

AnAZF1 (ANIA_06503) on chromosome 1 of Aspergillus nidulans encodes a C2H2-type zinc-finger transcription factor. The protein possesses RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase III type 1 promoter sequence-specific DNA binding, and 5S rRNA binding. It is associated with the positive regulation of transcription by RNA polymerase II, transcription initiation from a Pol III promoter, and 5S rRNA transcription. AnAZF1 has been linked to cellular responses to acidic pH, metal ions, and xenobiotic stimuli. The protein localises to the nucleus, cytosol, chromatin, and transcription regulator complexes. Studies of related genes in other species, including tomato ZAFA and yeast ZAP1, connect the family to metal-responsive gene regulation.