PYRG — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene pyrG (ANIA_06157) on chromosome 1 encodes a protein with orotidine-5'-phosphate decarboxylase and orotate phosphoribosyltransferase activities (EC 4.1.1.23), associated with de novo UMP biosynthesis. The gene is associated with aflatoxin metabolism, DNA integration, regeneration, sporocarp development involved in sexual reproduction, de novo pyrimidine base anabolism, pigment anabolism, asexual sporulation, DNA metabolism, glucose effect, melanin anabolism, nuclear division, aflatoxin anabolism, anaphase, homologous recombination, S phase, sporulation, and mitosis. Localised to the cytosol, pyrG is linked to phenotypes including altered adhesion, biofilm formation, filamentous and invasive growth, nutrient uptake and utilisation, stress resistance, autophagy, chronological lifespan, and auxotrophy. Studies of related genes in other species link the family to oxidative stress response.