BCR1 — Aspergillus nidulans FGSC A4

Summary

ANIA_06195 (BCR1, also known as creA) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a transcription factor with DNA-binding activity. It is associated with response to maltose, response to D-galactose, response to carbon starvation, regulation of penicillin anabolism, regulation of glycogen metabolism, carbohydrate utilization, depurination, pentose metabolism, proline breakdown, L-glutamate import, regulation of anabolism, proline metabolism, glycan biosynthesis, rhamnose breakdown, L-arabinose breakdown, downregulation of transcription from RNA polymerase II promoter by glucose, lactose breakdown, and CoA metabolism. The gene is linked to traits including sugar content, germination rate, and oxidative stress response. Phenotypic associations involve sporulation, cell cycle progression, meiosis, chromosome segregation, nuclear fusion during mating, pseudohyphal growth, adhesion, autophagy, and resistance to UV and ionizing radiation. Studies of related genes in other species link the family to virulence.