PKAC — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene PKAC (ANIA_06305) on chromosome 1 encodes a protein with a serine/threonine kinase domain, ATP binding, and lipid binding, and is annotated with cAMP-dependent protein kinase activity, protein kinase C activity, and novel protein kinase C activity. It is associated with the cAMP/PKA signaling cassette, regulation of aflatoxin anabolism, inhibition of sterigmatocystin anabolism, carbon catabolite repression, the glucose-sensing PKA pathway, downregulation of filamentous growth, positive regulation of ribosomal protein gene transcription, and regulation of response to osmotic stress. The encoded protein localizes to the cAMP-dependent protein kinase complex, nucleoplasm, stress granules, the division septum, and sites of polarized growth. Studies of related genes in other species link the PKA family to loss of pathogenicity and reduced virulence.