TOR — Aspergillus nidulans FGSC A4

Summary

ANIA_05982, symbol TOR and preferred name AnTOR on chromosome 1 of Aspergillus nidulans FGSC A4, encodes a non-specific serine/threonine protein kinase with histone H2A kinase activity, protein serine/threonine kinase activity, pre-rRNA binding, and protein complex binding. It belongs to the TOR catalytic and FRB domain families. The gene is associated with regulation of TOR signaling, DNA damage response and signal transduction, positive regulation of DNA-templated DNA replication and cytoplasmic translation, negative regulation of rDNA heterochromatin formation, and upregulation of cell growth. It localizes to the TOR complex, TORC1, nucleolar chromatin, and the ATR-ATRIP complex. Phenotypic associations include increased virulence, abnormal cell cycle progression, absent sporulation efficiency, increased nitrogen source utilization, and decreased polyploidy. Studies of related genes in other species link the family to oxidative stress response, protein content, and turgor pressure.