URA5 — Aspergillus nidulans FGSC A4

Summary

ANIA_05884 (URA5, also known as AnURA5 or URA10) on chromosome 1 encodes an orotate phosphoribosyltransferase (EC 2.4.2.10), a cytoplasmic enzyme associated with de novo UMP biosynthesis and pyrimidine nucleotide anabolism. The gene is associated with a wide range of phenotypes, including altered colony appearance, decreased sporulation and filamentous growth, abnormal chromosome maintenance, and changes in stress resistance, thermotolerance, and replicative lifespan. It is also linked to increased autophagy and pseudohyphal growth, as well as decreased biofilm formation, invasive growth, and carbon and nitrogen source utilisation. Related genes in other species connect the family to oxidative stress response and turgor pressure.