POT1 — Aspergillus nidulans FGSC A4

Summary

ANIA_05698 (POT1) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes a thiolase family protein with acetyl-CoA C-acetyltransferase (3-ketothiolase) activity (EC 2.3.1.16) and metal-binding capacity. The gene is associated with fatty acid beta-oxidation, primary and secondary metabolism, fermentation, and the pentose-phosphate shunt. It is linked to mitotic processes including spindle checkpoint, spindle elongation, anaphase, chromosome division, and mitotic exit, as well as phenylacetate breakdown. The product localises to peroxisomes and mitochondria. Related genes in other species link the family to acetyl-CoA C-acyltransferase activity (EC 2.3.1.9) and to plant pathogens such as Verticillium dahliae and Fusarium oxysporum.