aflM — Aspergillus nidulans FGSC A4

Summary

ANIA_05737 (aflM) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes a short-chain dehydrogenase/reductase (SDR) family protein with versicolorin reductase, mannitol 2-dehydrogenase (NADP+), and (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activities. The gene is associated with aflatoxin, sterigmatocystin, emodin, and abscisic acid anabolism, as well as sclerotium and conidiophore development, conidia formation, morphogenesis, protein homotetramerization, mannitol and fatty acid metabolism, and secondary metabolite biosynthesis. The product localizes to the vacuole, cytosol, and nucleus. Related genes in other species link the family to oxidoreductase activities (EC 1.1.1.138, 1.3.1.-).