atrR — Aspergillus nidulans FGSC A4

Summary

ANIA_05651 (atrR) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes a Zn(II)2Cys6 transcription factor with sequence-specific DNA-binding and RNA polymerase II cis-regulatory region binding activities. The gene is associated with positive and negative regulation of transcription by RNA polymerase II, positive regulation of metabolism, RNA elongation from the Pol II promoter, and DNA-dependent transcription. It is linked to cellular response to oxidative stress, biofilm formation, ergosterol anabolism, hypersensitivity, and negative regulation of the cellular response to drugs. The encoded protein localises to the nucleus, nuclear membrane, cytoplasm, and membrane. Studies of related genes in other species link the family to reduced virulence and pulmonary aspergillosis.