ACUD — Aspergillus nidulans FGSC A4

Summary

ANIA_05634 (ACUD) on Aspergillus nidulans chromosome 5 encodes an isocitrate lyase with both isocitrate lyase and methylisocitrate lyase activities (EC 4.1.3.1 and 4.1.3.30). The product localises to glyoxysomes and peroxisomes and is associated with the glyoxylate cycle, gluconeogenesis, acetate and fatty acid breakdown, catabolite repression, TCA cycle, sporulation, morphogenesis, and heterotrophy. The gene has been linked to numerous phenotypes including increased resistance to hydrostatic pressure, alkaline pH, hyperosmotic stress, and cold; increased viability, sporulation efficiency, and entry into G0; decreased apoptosis, autophagy, and mutation frequency; abnormal cell wall morphology, cytokinesis, colony appearance, and vegetative growth; and altered carbon and nitrogen source utilisation. Studies of related genes in other species connect the family to reduced virulence, oxidative stress response, and survival in stationary phase.