ACS1 — Aspergillus nidulans FGSC A4

Summary

ANIA_05626 (ACS1, AnACS1) on chromosome 5 encodes a protein with amide synthase activity and acetate-CoA ligase activity (EC 6.2.1.1), and binds AMP and ATP. The protein belongs to the AMP-dependent synthetase/ligase superfamily. In Aspergillus nidulans, ACS1 is associated with acetate and propionyl-CoA metabolism, acetoin breakdown, pyruvate fermentation to acetate, the glyoxylate cycle, carbon catabolite repression, protein acetylation, penicillin anabolism, and fruiting body formation. It localises to the cytosol, nucleolus, and extracellular. Phenotypic associations include abnormal carbon source utilisation, absent pheromone production and sensitivity, decreased hypoosmotic stress resistance, increased X-ray resistance, sterile phenotype, abnormal spore wall formation, and delayed cell cycle progression. Studies of related genes in other species link the family to protein content.