hxA — Aspergillus nidulans FGSC A4

Summary

ANIA_05613 (hxA, also known as AnXDH-1 or XDH-1) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes a xanthine dehydrogenase, an enzyme with xanthine dehydrogenase activity (EC 1.17.1.4) that binds FAD, a 2Fe-2S cluster, and molybdenum cofactor, and functions as a homodimer. The gene is associated with the breakdown of hypoxanthine, xanthine, guanine, nicotinate, and purine bases, as well as cellular responses to ammonia, nitrate, zinc, iron, cadmium, and copper. It is also linked to regulation of gene expression, signal transduction, and nonsense-mediated mRNA decay. The encoded protein localises to the peroxisome and cytoplasm.