FRQ1 — Aspergillus nidulans FGSC A4

Summary

ANIA_05341 (FRQ1, AnFRQ1) on chromosome 5 encodes a recoverin-family calcium-binding protein with EF-hand domains. The gene product is annotated as a 1-phosphatidylinositol 4-kinase activator, a calcium-dependent protein serine/threonine phosphatase regulator, and a phosphatase activator, and it binds calcium ions and phosphatases. FRQ1 is associated with calcineurin-mediated signaling, PIP biosynthesis, calcium signaling, cellular calcium ion homeostasis, downregulation of calcium import, regulation of cell morphogenesis and signal transduction, endocytosis, and spore formation. It localizes to the plasma membrane, trans-Golgi network membrane, cell division site, calcineurin complex, cytoplasm, cytosol, and nucleus. Phenotypic associations include abnormal Golgi and cytoskeleton morphology, decreased chitin deposition, absent cytokinesis and spindle morphology, increased alkaline pH resistance, increased desiccation and starvation resistance, decreased apoptosis, and altered endocytosis, budding, vacuolar transport, and meiosis. Related genes in other species link the family to starvation resistance and nucleolar size.