ATRR — Aspergillus nidulans FGSC A4

Summary

ANIA_05318 (ATRR) on Aspergillus nidulans chromosome 5 encodes a multidomain protein with thioester reductase-like, fatty acyl-CoA reductase NAD-binding, polyketide synthase phosphopantetheine-binding, acyl carrier protein, AMP-binding, and short-chain dehydrogenase/reductase domains. The gene is annotated with L-aminoadipate-semialdehyde dehydrogenase, ketoacyl-ACP synthase, fatty acid synthase, ligase, oxidoreductase, isomerase, and methyltransferase activities, and phosphopantetheine binding. ATRR is associated with amino acid activation for nonribosomal peptide biosynthesis, polyketide and toxin biosynthesis, monocarboxylic acid and fatty acid anabolism, ergosterol biosynthesis, secondary metabolite production, biofilm formation, methylation, and hypersensitivity. The product localises to the cytoplasm. Related genes in other species are linked to N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity and additional oxidoreductase functions.