SSA1 — Aspergillus nidulans FGSC A4

Summary

AnSSA1 (SSA1) on chromosome 5 of Aspergillus nidulans encodes an Hsp70 family chaperone with ATP hydrolase activity, ATP binding, heat shock protein binding, and protein folding chaperone functions, and it also acts as a transcriptional co-regulator. The gene is associated with protein refolding, cellular homeostasis, sulfur and secondary metabolism, the cellular response to farnesol, osmotic response, signal transduction, regulation of gene expression, filamentous growth, cell growth, the cell cycle, mitosis, anaphase, and hypersensitivity. Its product localises to the cytoplasm, cytosol, nucleus, plasma membrane, fungal-type cell wall, and extracellular. AnSSA1 is associated with increased thermotolerance, altered cell cycle progression, premature apoptosis, abnormal spore germination, increased polyploidy, and changes in chemical compound accumulation, nutrient uptake, and prion inheritance. Studies of related Hsp70 family members in other species connect the family to oxidative stress response and acid sensitivity.