TBP — Aspergillus nidulans FGSC A4

Summary

ANIA_04976 (TBP, AnTBP) on chromosome 3 encodes a TATA-box-binding protein with a TBP_eukaryotic domain. The gene product binds TFIIA-class transcription factors, RNA polymerase I, II and III general initiation factors, and chromatin, and is associated with preinitiation complex assembly and transcription initiation for all three RNA polymerases. AnTBP localises to the nucleus as part of the TFIID, TFIIA, TFIIIB and Pol I transcription regulator complexes. The gene is associated with numerous phenotypes including absent growth in exponential phase, decreased G1/S cell cycle progression, delayed anaphase and metaphase, absent meiosis and mating-type switching, absent desiccation resistance, increased X-ray resistance, decreased ribophagy, and abnormal transposable element transposition, telomere length and mutation frequency. Related genes in other species link the TBP family to similar transcription initiation functions.