PMC1 — Aspergillus nidulans FGSC A4

Summary

AnPMC1 (ANIA_04920) on chromosome 3 of Aspergillus nidulans encodes a P-type ATPase of the IIB subfamily, with annotated P-type potassium:proton transporter, K+-transporting ATPase, P-type sodium transporter, P-type manganese transporter, P-type calcium transporter, and proton-transporting ATPase activities, as well as ATP hydrolase activity, ATP binding, calcium ion binding, and metal binding. The gene is associated with potassium, sodium, calcium, and manganese ion transport and homeostasis, proton export, cell pH reduction, folate biosynthesis, and the unfolded protein response. Its product localises to the plasma membrane, vacuolar membrane, Golgi membrane, ER membrane, and nuclear envelope. AnPMC1 is linked to calcium sensitivity, abnormal Golgi distribution and morphology, absent spore germination, increased ionic stress resistance, and numerous defects in endocytosis, vacuolar transport, micronucleophagy, and cell cycle progression. Related genes in other species are associated with calcium-transporting ATPase activity and, in some species, with reduced virulence.