BD — Aspergillus nidulans FGSC A4

Summary

ANIA_04685 (BD, AnBD) on Aspergillus nidulans chromosome 3 encodes a small GTPase of the Ras-type family, possessing GTP, GDP, CTP and UTP binding activities, GTPase activity and protein serine/threonine kinase activator activity. The gene is associated with the cAMP/PKA signaling cassette, upregulation of Rho protein signal transduction, positive regulation of the pheromone response MAPK cascade, cell-abiotic substrate adhesion, axial bud site selection, regulation of cell polarization, cellular response to glucose stimulus, and maintenance of protein location in the cell. It localizes to the plasma membrane, cytoplasm, vacuolar membrane, division septum, cellular bud neck, incipient cellular bud site, cortical dynamic polarity patch, and mating projection actin fusion focus. Phenotypic associations include absent bipolar budding pattern, decreased budding rate, increased mating type switching, decreased rate of entry into G0, absent osmotic and oxidative stress resistance, decreased flocculation, and delayed nuclear export. Related genes in other species are linked to reduced virulence and oxidative stress response.