CLR6 — Aspergillus nidulans FGSC A4

Summary

ANIA_04493 (symbol CLR6, also known as AnCLR6 or AnRPD3) encodes a histone deacetylase (EC 3.5.1.98) with NAD-independent histone deacetylase activity, including activity toward histones H3-K9, H3-K14, H4-K5, H4-K8, H4-K12 and H4-K16. The product contains a His_deacetylse domain and is a component of several chromatin-modifying complexes, including the HDA1, Rpd3S, SHREC and SET3C complexes. In Aspergillus nidulans, CLR6 is associated with epigenetic downregulation of gene expression, heterochromatin island and rDNA heterochromatin assembly, centromeric silencing, and regulation of phenotypic switching. It is also linked to filamentous growth in response to pH, starvation and biotic stimuli, as well as appressorium formation. Phenotypic associations include abnormal cell cycle progression, mating-type switching, flocculation, sporulation rate, biofilm formation and nutrient uptake. Related genes in other species are linked to acid sensitivity.