TUP1 — Aspergillus nidulans FGSC A4

Summary

ANIA_04456 (TUP1) on Aspergillus nidulans chromosome 3 encodes a putative small nucleolar ribonucleoprotein complex subunit containing WD40 repeats. The product is associated with diverse molecular functions including U3 snoRNA, ribosome, microtubule plus-end, dynein complex, histone deacetylase, mediator complex, and G-alpha protein subunit binding, as well as PKC binding, signaling receptor activator activity, translation regulator activity, and GDI activity. It is linked to numerous biological processes such as carbon catabolite repression, regulation of glycogen and amino acid metabolism, siderophore metabolism, arginine breakdown, GPCR and GCN2-mediated signaling, positive regulation of autophagy, negative regulation of translational frameshifting and cell integrity MAPK cascade, and microtubule organizing center organization. The protein localises to the box C/D methylation guide snoRNP complex, transcription repressor complex, Tup11/Tup12 repressor complex, SSU processome, spindle pole, and extracellular vesicle. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.