CPR2 — Aspergillus nidulans FGSC A4

Summary

ANIA_04467 (CPR2) on chromosome 3 of Aspergillus nidulans encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) with cyclosporin A binding and cis-trans proline isomerase activity. The protein localises to the ER lumen, Golgi complex, fungal-type vacuole, membrane, cytoplasm and extracellular space. It is associated with protein folding in the ER, invasive growth, and a wide range of phenotypes including abnormal colony colour, cell cycle arrest at metaphase-anaphase, delayed endocytosis, altered nuclear transport, increased cell death, increased mitophagy, decreased invasive growth, altered budding index, decreased osmotic stress resistance, increased sporulation efficiency, and altered carbon source utilisation and respiratory metabolism. Related genes in other species are linked to increased stationary-phase survival.