tcsB — Aspergillus nidulans FGSC A4

Summary

ANIA_04447 (tcsB) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes a histidine kinase with osmosensor activity, histidine phosphotransfer kinase activity, and phosphorelay sensor kinase activity, classified as EC 2.7.13.3. The protein contains HisK dimerisation, HATPase, and CheY-like receiver domains, and is localised to the plasma membrane. tcsB is associated with osmolarity sensing via a two-component system, histidyl-aspartyl phosphorelay, MAPK cascade, morphogenesis, cell cycle, host invasion, and signal transduction. It is also linked to iron-sulfur cluster assembly and its upregulation.