AM — Aspergillus nidulans FGSC A4

Summary

ANIA_04376 (AnAM) encodes a glutamate dehydrogenase with NADP+ activity (EC 1.4.1.4), belonging to the Glu/Leu/Phe/Val/Trp dehydrogenase family. In Aspergillus nidulans, this gene is associated with nitrogen utilization, the TCA cycle, and cellular response to farnesol. It has been linked to DNA-mediated transformation and chromatin modeling. The protein localizes to both the cytosol and extracellular space. Phenotypic associations include abnormal filamentous growth, decreased nitrogen source utilization, decreased necrotic cell death, increased mating response, increased osmotic stress resistance, increased vegetative growth rate, and increased carbon source utilization. Additional associations include decreased nutrient uptake, abnormal redox state, increased silencing, and abnormal peroxisomal morphology and transport. Studies of related genes in other species link the family to nitrogen metabolism and stress responses.