TEF1 — Aspergillus nidulans FGSC A4

Summary

ANIA_04218 (TEF1, AnTEF1) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes elongation factor 1-alpha, a GTP-binding protein with GTPase and translation elongation factor activity. The gene is associated with translation elongation, translation, secretion, pseudohyphal growth, digestion, and development processes including CNS and nervous system development, organogenesis, and embryogenesis. The product localises to the cytoplasm. Phenotypic associations include absent spore wall formation, abnormal prion inheritance and formation, absent innate thermotolerance, absent meiosis, increased necrotic cell death, delayed autophagy and pexophagy, altered cell cycle progression through G2/M, decreased budding and endocytosis rates, increased carbon source utilisation and nutrient uptake, and abnormal shmoo formation and pseudohyphal growth. Studies of related genes in other species link the family to days to silk and protein content in maize.